My brother in law, Dr Jeff Bradstreet, was a physician known for his work in integrative medicine and autism research.
One of the areas he explored extensively was the immune protein GcMAF, which he believed could help correct immune dysfunction seen in some chronic illnesses.
Below is an explanation of what he believed, why he used it, and the biological mechanism he focused on.
When he had first discovered it and was learning and researching about GcMAF and the history of it he had called Thom to share with him all of the amazing benefits of GcMAF.
He believed that everyone could benefit and he also believed this was the answer to curing many illnesses and conditions such as cancer, autism, auto immune disorders and more. I remember Thom sharing this with me and being so intrigued by this protein.
He told us we needed to incorporate it into our health protocol as a preventative and also to boost our immune system. He was't suggesting to stay on it long term but rather to do GcMAF therapy once or twice a year if we did not have any serious health conditions. Those with serious health conditions would need a more intensive GcMAF protocol.
Jeff's Theory: Chronic Illness and Immune Suppression
Jeff believed that many chronic conditions—including autism and cancer—shared a common problem: suppressed macrophage activity.
Macrophages are immune cells responsible for:
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destroying infected cells
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clearing toxins and pathogens
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regulating inflammation
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coordinating immune responses
When macrophages are not functioning properly, the immune system can struggle to control infections or abnormal cells.
He believed a major cause of this suppression was an enzyme called Nagalase. ( I have made many posts regarding nagalase and have the kits on my website)
Nagalase is an enzyme that can be produced by:
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certain viruses
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cancer cells
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some pathogens
Jeff and other researchers suggested that elevated nagalase could block the body’s natural production of GcMAF.
The proposed mechanism was:
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The body produces Vitamin D Binding Protein.
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Normally, immune enzymes convert it into GcMAF, which activates macrophages.
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Nagalase interferes with this conversion.
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Without GcMAF, macrophages remain underactive.
This could lead to:
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impaired pathogen clearance
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chronic inflammation
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immune dysregulation
Due to his findings regarding nagalase he believed that supplementing GcMAF externally could bypass the nagalase blockade.
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If macrophages were activated again,
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the immune system could resume clearing pathogens, toxins, or abnormal cells.
He reported observing improvements in some patients with:
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autism spectrum disorders
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chronic viral infections
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immune dysregulation
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cancer
He also emphasized that authentic GcMAF must come from human vitamin D binding protein because macrophage receptors recognize a very specific structure.
I remember being part of a conversation with him and Thom and Jeff explaining why it had to be from human serum which made complete sense to me.
In fact, prior to his murder he was discussing with Thom that his goal was to eventually have GcMAF manufactured here in the USA. He was discussing this with Thom due to our extensive knowledge in our food manufacturing company which gave Thom experience in production and running a production facility.
That would have taken some mighty hoops to go through and a lot of prayer in order to get approval and even the possibility of having it made here. His desire was for as many people to access it as possible.
To Summarize Why Jeff Only Used Human Derived GcMAF:
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synthetic or plant substitutes would not trigger the same immune signaling
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the exact glycosylation pattern on the human protein was critical
That is why serum-derived preparations were used in early research.
His work centered on restoring immune balance, especially in patients he believed had:
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chronic infections
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environmental toxin exposure
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neuroimmune inflammation
He saw GcMAF as one potential tool to restart immune surveillance.
You can visit here for GcMAF products: https://ourlittlewhitebarn.com
Written by Candice Bradstreet